The ozone layer: the road not taken
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The road not taken.
The Road Not Taken Two roads diverged in a yellow wood, And sorry I could not travel both And be one traveler, long I stood And looked down one as far as I could To where it bent in the undergrowth; Then took the other, as just as fair, And having perhaps the better claim, Because it was grassy and wanted wear; Though as for that, the passing there Had worn them really about the same, And both ...
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In this issue of Clinical Cancer Research, Hong, et al (1) report on the safety and tolerability of LY2275796, a second generation antisense oligonucleotide (ASO) targeted to the eukaryotic translational initiation factor eIF-4E mRNA, a gene that has been reported to play a role in tumor initiation. In the study, ASO MTD and biologic effective dose was set at 1000 mg, due to a DLT of grade 3 fa...
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In the post-genomic era the complex problem of evolutionary biology can be tackled from the top-down, the bottom-up, or from the middle-out. Given the emergent and contingent nature of this process, we have chosen to take the latter approach, both as a mechanistic link to developmental biology and as a rational means of identifying signaling mechanisms based on their functional genomic signific...
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ژورنال
عنوان ژورنال: Nature
سال: 1996
ISSN: 0028-0836,1476-4687
DOI: 10.1038/381551a0